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Even with all modern therapeutic advancements, a proportion of individuals will nonetheless are unsuccessful to respond and should be regarded as for curative therapy. Currently, only allogeneic hematopoietic mobile transplantation can be considered most likely curative, but it is also connected to substantial morbidity and mortality.
103,104 Both of those trials concluded that early therapy in asymptomatic sufferers wasn't linked to a chronic overall survival. Very recently, preliminary final results from a 3rd demo comparing ibrutinib vs .